ABSTRACT
Nitrofurazone is a nitrofuran topical antibacterial agent with bactericidal activity against a number of pathogens, including Staphylococcus aureus and Escherichia coli; it does also have significant activity against Pseudomonas aeruginosa, Proteus mirabilis, and Serratia marcescens. This chapter provides monographs of nitrofurazone which have caused contact allergy/allergic contact dermatitis. The monographs present: identification section; contact allergy (general population, patients with dermatitis, case reports and case series); cross-reactions; patch test sensitization; photocontact allergy; and immediate contact reactions (contact urticaria). The identification section presents IUPAC names, synonyms, CAS and EC numbers, structural and chemical formulas, Merck Index monographs, and advises on patch testing. The chapter also covers an extensive amount of information to benefit dermatologists, allergists, and all others interested in drug allergy.
