ABSTRACT
Pheniramine is a first generation antihistamine in the alkylamine class. It is used in some over-the-counter allergy as well as cold & flu products in combination with other drugs. Pheniramine’s use as an anti-allergy medication for hay fever, rhinitis, allergic dermatoses, and pruritus has largely been supplanted by second generation antihistamines. This chapter provides monographs of pheniramine which have caused contact allergy/allergic contact dermatitis. The monographs present: identification section; contact allergy (general population, patients with dermatitis, case reports and case series); cross-reactions; patch test sensitization; photocontact allergy; and immediate contact reactions (contact urticaria). The identification section presents IUPAC names, synonyms, CAS and EC numbers, structural and chemical formulas, Merck Index monographs, and advises on patch testing. The chapter also covers an extensive amount of information to benefit dermatologists, allergists, and all others interested in drug allergy.
