ABSTRACT
Phenylbutazone is a synthetic pyrazolone derivative and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, antipyretic, and analgesic activities. Phenylbutazone was formerly used for the treatment of backache, ankylosing spondylitis, rheumatoid arthritis, and reactive arthritis. This chapter provides monographs of phenylbutazone which have caused contact allergy/allergic contact dermatitis. The monographs present: identification section; contact allergy (general population, patients with dermatitis, case reports and case series); cross-reactions; patch test sensitization; photocontact allergy; and immediate contact reactions (contact urticaria). The identification section presents IUPAC names, synonyms, CAS and EC numbers, structural and chemical formulas, Merck Index monographs, and advises on patch testing. The chapter also covers an extensive amount of information to benefit dermatologists, allergists, and all others interested in drug allergy.
