ABSTRACT
Pilocarpine is a natural alkaloid extracted from plants of the genus Pilocarpus with cholinergic agonist activity. As a cholinergic parasympathomimetic agent, it predominantly binds to muscarinic receptors, thereby inducing exocrine gland secretion and stimulating smooth muscle in the bronchi, urinary tract, biliary tract, and intestinal tract. This chapter provides monographs of pilocarpine which have caused contact allergy/allergic contact dermatitis. The monographs present: identification section; and contact allergy (general population, patients with dermatitis, case reports and case series). The identification section presents IUPAC names, synonyms, CAS and EC numbers, structural and chemical formulas, Merck Index monographs, and advises on patch testing. The chapter also covers an extensive amount of information to benefit dermatologists, allergists, and all others interested in drug allergy.
