ABSTRACT
Polymyxin B is a mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains, with antibacterial activity. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. This chapter provides monographs of Polymyxin B which have caused contact allergy/allergic contact dermatitis. The monographs present: identification section; contact allergy (general population, patients with dermatitis, case reports and case series); cross-reactions; patch test sensitization; photocontact allergy; and immediate contact reactions (contact urticaria). The identification section presents IUPAC names, synonyms, CAS and EC numbers, structural and chemical formulas, Merck Index monographs, and advises on patch testing. The chapter also covers an extensive amount of information to benefit dermatologists, allergists, and all others interested in drug allergy.
