ABSTRACT
This chapter provides monographs of prednisolone acetate which have caused contact allergy/allergic contact dermatitis. The monographs present: identification section; contact allergy (general population, patients with dermatitis, case reports and case series); cross-reactions; patch test sensitization; photocontact allergy; and immediate contact reactions (contact urticaria). The identification section presents IUPAC names, synonyms, CAS and EC numbers, structural and chemical formulas, Merck Index monographs, and advises on patch testing. The chapter also covers an extensive amount of information to benefit dermatologists, allergists, and all others interested in drug allergy. In Leuven, Belgium, between 1990 and 2017, 16,065 patients were investigated for contact allergy and 118 (0.7%) showed positive patch test reactions to topical ophthalmic medications and/or to their ingredients. Eighty-four individuals (71%) reacted to an active principle. Prednisolone acetate was tested in 57 patients and was the allergen in eye medications in 4. There were no reactions to prednisolone acetate in other types of medications (2).
