ABSTRACT
Pyrazinobutanone is a nonsteroidal anti-inflammatory drug (NSAID) which has anti-inflammatory properties and is an equimolar salt of phenylbutazone and piperazine. Its clinical use is similar to other related NSAIDs, but its digestive tolerance is said to be superior. This chapter provides monographs of pyrazinobutazone which have caused contact allergy/allergic contact dermatitis. The monographs present: identification section; contact allergy (general population, patients with dermatitis, case reports and case series); cross-reactions; patch test sensitization; photocontact allergy; and immediate contact reactions (contact urticaria). The identification section presents IUPAC names, synonyms, CAS and EC numbers, structural and chemical formulas, Merck Index monographs, and advises on patch testing. The chapter also covers an extensive amount of information to benefit dermatologists, allergists, and all others interested in drug allergy.
