ABSTRACT
Pyrrolnitrin is a pyrrole antifungal agent isolated from several Pseudomonas species including Pseudomonas pyrrocinia. It is effective mainly against Trichophyton, Microsporum, Epidermophyton, and Penicillium. It was formerly marketed in Italy, Spain and Japan, but is nowadays probably hardly, if at all, used anymore in topical antifungal preparations. This chapter provides monographs of pyrrolnitrin which have caused contact allergy/allergic contact dermatitis. The monographs present: identification section; contact allergy (general population, patients with dermatitis, case reports and case series); cross-reactions; patch test sensitization; photocontact allergy; and immediate contact reactions (contact urticaria). The identification section presents IUPAC names, synonyms, CAS and EC numbers, structural and chemical formulas, Merck Index monographs, and advises on patch testing. The chapter also covers an extensive amount of information to benefit dermatologists, allergists, and all others interested in drug allergy.
