ABSTRACT
Sulfadiazine silver is a sulfonamide-based topical agent which is bactericidal for many gram-negative and gram-positive bacteria as well as being effective against yeast. Silver sulfadiazine may act through a combination of the activity of silver and sulfadiazine. This chapter provides monographs of sulfadiazine silver which have caused contact allergy/allergic contact dermatitis. The monographs present: identification section; contact allergy (general population, patients with dermatitis, case reports and case series); cross-reactions; patch test sensitization; photocontact allergy; and immediate contact reactions (contact urticaria). The identification section presents IUPAC names, synonyms, CAS and EC numbers, structural and chemical formulas, Merck Index monographs, and advises on patch testing. The chapter also covers an extensive amount of information to benefit dermatologists, allergists, and all others interested in drug allergy.
