ABSTRACT
Triethanolamine polypeptide oleate condensate (TPOC) is a condensation product of triethanolamine, peptides and oleic fatty acids. It is used as a cerumenolytic drug, a compound to dissolve earwax. This chapter provides monographs of TPOC which have caused contact allergy/allergic contact dermatitis. The monographs present: identification section; contact allergy (general population, patients with dermatitis, case reports and case series); cross-reactions; patch test sensitization; photocontact allergy; and immediate contact reactions (contact urticaria). The identification section presents IUPAC names, synonyms, CAS and EC numbers, structural and chemical formulas, Merck Index monographs, and advises on patch testing. The chapter also covers an extensive amount of information to benefit dermatologists, allergists, and all others interested in drug allergy.
