ABSTRACT

Tromantadine is a cyclic amine derived from amantadine with activity against Herpes simplex virus. It inhibits absorption of virions to cell surfaces, as well as penetration and uncoating of the virus. It is used in the topical treatment of herpes simplex. This chapter provides monographs of tromantadine which have caused contact allergy/allergic contact dermatitis. The monographs present: identification section; contact allergy (general population, patients with dermatitis, case reports and case series); cross-reactions; patch test sensitization; photocontact allergy; and immediate contact reactions (contact urticaria). The identification section presents IUPAC names, synonyms, CAS and EC numbers, structural and chemical formulas, Merck Index monographs, and advises on patch testing. The chapter also covers an extensive amount of information to benefit dermatologists, allergists, and all others interested in drug allergy.