ABSTRACT

In cases of allergic contact dermatitis from topical pharmaceuticals, the allergenic culprit may be either the active drug or one or more of the other components, for example vehicle ingredients, preservatives, antioxidants, fragrances or other chemicals present in the topical drug product. This chapter provides monographs of allergic contact dermatitis to ingredients other than the active drug which have caused contact allergy/allergic contact dermatitis. The monographs present: identification section; contact allergy (general population, patients with dermatitis, case reports and case series); cross-reactions; patch test sensitization; photocontact allergy; and immediate contact reactions (contact urticaria). The identification section presents IUPAC names, synonyms, CAS and EC numbers, structural and chemical formulas, Merck Index monographs, and advises on patch testing. The chapter also covers an extensive amount of information to benefit dermatologists, allergists, and all others interested in drug allergy.