ABSTRACT
Acetazolamide is Indicated for the treatment of hypercapnia due to chronic obstructive pulmonary disease, idiopathic intracranial hypertension, prevention or treatment of postoperative intraocular pressure after cataract surgery, absence seizures and prophylaxis of acute mountain sickness. One day after application of 10% acetazolamide cream under a compression panty following liposuction of the thighs, a 32-year-old woman developed a skin eruption at the application site, which spread to the face, arms and neck, but not to the trunk. Patch tests were positive to the cream at D2. A patch test with the commercial cream was positive. The application of the cream under occlusion, which is contra-indicated according to the prescription of the pharmaceutical, may have facilitated spreading of the dermatitis. Cutaneous adverse drug reactions from systemic administration of acetazolamide caused by type IV hypersensitivity, including maculopapular exanthema and acute generalized exanthematous pustulosis, are planned to be discussed in Volume IV of the Monographs in Contact Allergy series on Systemic drugs.
