ABSTRACT
Self-organization paradigm in tissue morphogenesis is emerging its potential power for regenerating injured tissue for regenerative medicine. It overcomes some limitations associated with the usage of scaffolds with specific structures since the fabricated mechanical scaffolds cannot totally possess the complexity of native tissues. Tubular or hollow structures serve as fundamental units in most organs. The hollow cellular structures can also be constructed by 3D bioprinter using the biomimetic components made of biomaterials such as hydrogels encapsulating cells. This chapter discusses a simulation model that describes an engineered composite hydrogel structure with interfacial planes inside it to serve as the 3D culture matrix to sculpt the 3D multicellular structures. It investigates the 3D pattern formation process of vascular mesenchymal cells at the interfaces between hydrogels with different components and mechanical properties.
