ABSTRACT
The approach for the design and construction of these diacylglycerols (DAG)-lactones was based on the use of enantiopure small molecules, principally obtained from natural sugars. This is known as the chiron approach, in which the syntheses of the target molecules start from optically active sugars in order to establish the desired stereochemistry. To determine the total number of isomeric DAG-lactones generated by this process, one has to take into account the formation of an extra chiral center during the cyclization process. The approach for the design and construction of these DAG-lactones was based on the use of enantiopure small molecules, principally obtained from natural sugars. This is known as the chiron approach, in which the syntheses of the target molecules start from optically active sugars in order to establish the desired stereochemistry. The syntheses of the compounds presented important challenges for the preparation of either racemic or enantiopure molecules.
