ABSTRACT
Leukemic infiltration of the prostate was first described by Ascoli in 1933. The stroma propria is infiltrated by myeloblasts, developing granulocytes, and eosinophil metamyelocytes. Transurethral resection of the prostate (TURP) in these patients is commonly associated with infection and hemorrhage. Primary lymphoma of the prostate is virtually always diffuse. In the microscopic sections the fibromuscular stroma of the prostate is diffusely infiltrated by the neoplastic lymphocytic elements. The malignant lymphocytes often form cords or single files and infiltrate the stroma propria parallel to the orientation of the muscle fibers. The normal prostatic ducts and acini exhibit resistance to the spreading tumor cells. The basement membrane of the prostatic glands is seldom violated. Malignant lymphoma of the prostate must be separated from nonspecific chronic prostatitis. Malignant angioendotheliomatosis (MAE) is a multifocal neoplastic condition characterized by proliferation of malignant cells within the lumen of small blood vessels.
