Indeed, no one can challenge the popularity and beneficial use of electronic devices, including general electronic appliances, television, computer, laptop, wireless, mobile phones, and their role in daily-life activities. However, all these devices generate radiofrequency electromagnetic field radiation (RF-EMFR). The widespread use of smartphones and the impact of non-ionizing radiation generated from these devices raises concerns about adverse health effects on human health. The brain is susceptible and affected by RF-EMFR due to proximity to a mobile phone during a call, which can last from minutes to hours per day. The analysis of various animal and human model studies, free from favoritism and financial conditioning, reveals a relationship between RF-EMFR and adverse effects on the brain. These adverse effects include headaches, fatigue, sleep disturbances, behavioral problems, memory, neurocognitive function impairment, and an increased risk of developing brain tumors. The WHO also classified these radiations as possibly carcinogenic, increasing the risk of malignant brain tumors [International Agency for Research on Cancer, “IARRC classifies radiofrequency electromagnetic fields as possibly carcinogenic to humans,” Press Release No 2008, 2011. View at: Google Scholar]. Health authorities must take directives to minimize public exposure to RF-EMFR by regulating the usage of mobile phones and avoid installing the mobile phone base-station towers in or near residential and thickly populated areas.