ABSTRACT
Darwinian evolution is focused on material competition between organisms, whereas cellular epigenetic evolution is predicated on cell-cell communication of from one stage of life to another-developmentally, phylogenetically, as injury-repair ultimately governed by the First Principles of Physiology. This mode of evolution is founded on ontogeny as the only known mechanism for the formation of biologic structure and function. Cell-cell communication is the basis for forming complicated phenotypes mediated by high energy phosphates as ‘second messengers’. Such messengers affect the transcription of DNA within the nucleus, leading to translation to RNA and protein, which is the ‘central dogma’ of biology the proteins affecting either growth or differentiation of the affected cell. Primordial cells spontaneously formed from micelles with semipermeable cell membranes that accommodated acquisition of various substances. Internal membranes then compartmentalized such substances and organized them biochemically, forming the basis for physiology.
