ABSTRACT
Cell micromanipulation is a kind of microbiological operation technology that can complete the gene operation of cells or embryos by using a biological microscope. This process involves various cell operations, such as localization, nuclear transfer, cutting, and injection. As the most widely used technology in cell micromanipulation, cell micropuncture has an irreplaceable medical value in the field of physiology, pathology, and pharmacology. In addition, biological cells with small size are usually very fragile; the operating instrument must have high precision to realize cell micropuncture with controlled puncture force. This chapter presents the research background, existing problems, research objectives, and significance of this book. The present book aims to (1) unify existing and emerging techniques concerning micropuncture robot system with piezo actuators; (2) provide a series of latest results in, including but not limited to, design, optimization, modeling, and control of micropuncture using piezoelectric actuator; (3) capture recent advances of theory, technological aspects, and applications of advanced actuation, modeling and control methodologies in biomedical engineering applications; and (4) give simulation and/or experimental results to demonstrate the main focus of the design, analysis, and synthesis approaches.
