The process behind biomedical informatics includes data analysis and data interpretation, which are considered the significant tasks in risk determination. Risk analysis and disease prediction in bioinformatics include the applicability of computational techniques to formulate their goal. Informatics techniques such as statistics, machine learning, soft computing, swarm intelligence, data mining, and data visualization have been used in medical data. Bioinformatics can be broadly classified into three types based on the data type to be processed to frame the decision support model. They are bioinformatics, imaging informatics, and public health informatics. The health sector needs to be improved by enhancing medical facilities, determining disease-specific risk factor, and spreading health awareness. Epidemiological study is mainly concerned with the analysis, occurrence, and distribution of demographics of disease statistics for the specified region or country. The software that are meant for bio-programming and bioinformatics are designed for sequence and structural analysis for biological databases.