ABSTRACT

Microfluidic biochips have been considered as one of the key technologies for automatic sample preparation that includes dilution and mixing of fluids in certain ratios. Dilution and mixing are implemented on biochips through a sequence of basic fluid-mixing and splitting operations. This chapter discusses a storage-aware sample preparation method for mixing two or more biochemical reagents on a CFMB which addresses these issues. Mixing algorithm basically follows the same idea as the method for dilution. Boolean satisfiabiliy solvers are utilized to determine the option that gives the minimum reagent usage and, at the same time, satisfies the limitations in storage elements.