ABSTRACT
This chapter discusses and describes the basics of endocrine modeling. Modeling in endocrinology depends on sound understanding of developmental events, proliferation, growth, differentiation, physiology, biochemistry, and metabolism. Specializations include, among others, mainly endocrine sub systems like the hypothalamus–pituitary–thyroid system, the glucose–insulin control system, hypothalamus–pituitary–gonadal system, and the hypothalamus–pituitary–adrenal system. In biological research, a wide range of different models – phenomenological, computational, and of course, mathematical – can be applied on various areas of biology. Mathematical modeling is intended to be transparent and understandable. Every attempt should be made to avoid unnecessary mathematical complexity, bearing in mind an Occam’s razor approach, which seeks to find a model that balances mechanistic realism and mathematical simplicity. Regarding the endocrine and pharmacokinetic aspects, the human body can, in its simplest way, be considered as a liquid container with all kinds of compartmentalized metabolic processes necessary for survival.
