ABSTRACT
The skin comes into contact with many toxic agents. Fortunately, it has a good lipid barrier and is, therefore, not highly permeable. The skin of the chemically sensitive individual is an important interface between the internal organs and environmental pollutants. The oily layer of the skin of the chemically sensitive individual can be damaged by contact with solvents in bathing water or by contact with chemicals contained in a variety of common products used in the home or workplace. Toxic chemicals are more readily absorbed when in contact with intertriginous areas of the body in contrast to the glabrous skin. The mechanisms of actions of toxic chemicals on the skin of the chemically sensitive are diverse. The effects of toxic chemicals upon the skin of chemically sensitive individuals are becoming very well known. The most recognized reaction to pollutant exposure is necrolysis. Erythema multiforme and severe drug reactions also commonly result from toxic chemical exposures.
