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Chapter

Bioequivalence Testing Protocols

Chapter

Bioequivalence Testing Protocols

DOI link for Bioequivalence Testing Protocols

Bioequivalence Testing Protocols book

Bioequivalence Testing Protocols

DOI link for Bioequivalence Testing Protocols

Bioequivalence Testing Protocols book

BySarfaraz K. Niazi
BookHandbook of Pharmaceutical Manufacturing Formulations

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Edition 3rd Edition
First Published 2019
Imprint CRC Press
Pages 12
eBook ISBN 9781315102948

ABSTRACT

Highly volatile solvents may contribute to premature drying near the nozzle tip resulting in poor film integrity or spray drying. As particles move through the spray region, coat solution or suspension spray droplets contact the particles as solvent in the coat formulation is evaporated. One purpose of flavoring is to minimize exposure of orally delivered solid drug substances to the sensor system responsible for taste perception. Oral formulations are subject to several hurdles, including making the appearance appealing, overcoming swallowing limitations, the mouthfeel, taste, and smell, to allow an oral product to be accepted by patients. In addition to the ability to uniformly coat particles to a controlled filmcoat thickness with the Wurster process, filmcoat formulations can be developed with the balance of concealing and drug release properties required for taste-concealing applications. Formulators should refer to the United States Pharmacopeia, National Formulary, or other applicable regulatory resources for lists of allowed taste-concealing formulation excipients.

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