ABSTRACT
The main determinant of the tissue supply of hormones is the hormone concentration in the blood, depending on hormone inflow into the blood as well as on hormone elimination from the blood. This determinant depends on two circumstances. On the one hand, when the hormone inflow into tissues increases, more active hormones reach the specific receptors, and therefore more hormones can be specifically bound by their own receptors. On the other hand, when the number of hormone receptors increases, the ratio between specific and unspecific binding sites is elevated. Most hormone molecules are bound by cellular proteins. The amount of available data is too small for drawing conclusions about the modulating regulation of hormone effects during exercise. Experiments on rats with adrenocortical or thyroid insufficiencies pointed to some significance of corresponding hormones. Besides the modulating regulation, attending regulation may also be actualized through: metabolic regulation, acting via the other receptors on cellular metabolism and thus changing the actualization of private regulation.
