ABSTRACT
The technique of chemical ionization (Cl), first introduced by Munson and Field^ in 1966, is a direct outgrowth of fundamental studies of ion/molecule interactions; as such the technique is based on the knowledge developed from these fundamental studies and makes use of the instrumentation developed for such studies. Since its initial introduction, chemical ionization mass spectrom etry (CIMS) has developed into a powerful and versatile tool for the identification and quantitation of organic molecules and, consequently, has found extensive application in many branches of chemistry and biochemistry and in medical and environmental fields.
