ABSTRACT
This chapter describes commonly used systems and components in terms of their overall configuration and operation, and their relative advantages and disadvantages as applied to biopharmaceutical processes. Automatic and semi-automatic cleaning equipment and systems are widely applied in the biopharmaceutical industry. Automatic cleaning systems require the automated addition of cleaning agents for reliable and repeatable operation. Air and electrically driven diaphragm pumps are quite often used for the automatic addition of cleaning agents to cleaning solutions. Electrically driven peristaltic pumps are used for the automatic addition of cleaning agents to cleaning solutions. Automatic and semi-automatic cleaning equipment and systems are widely applied in the biopharmaceutical industry. The single-use of washing solution is often employed in the cleaning of biopharmaceutical equipment due to concerns about residue carry-over between clean-in-place (CIP) circuits. Portable CIP Systems typically require a relatively low degree of control system sophistication as compared with other CIP systems.
