ABSTRACT
This chapter is concerned with the interactions of solids with liquids. It deals with covalent solids, organic solids used as drugs having received particular attention. The chapter is concerned with ionic systems. Use of the vaporization or sublimation enthalpy of a solid at 25°C less the expansion work RT but uncorrected for the crystal-liquid transition does not yield a Hildebrand parameter, although this cohesion parameter value may be valuable for other purposes. The cohesive properties of solids have been emphasized by Kendall, while Aeree has reviewed the use of the Hildebrand-Scatchard model to predict activity coefficients and solubilities for solid solutes in liquids. An alternative approach is the calculation of the cohesive energies of solids from their structures using the appropriate atomic parameters, such as that carried out for Ti4O7 by Iguchi and Matsushima. Component cohesion parameters have not been used widely in the correlation of solid-liquid solubilities.
