ABSTRACT
Solubility is of major importance in biological processes, and correlations with cohesion properties have been explored for such purposes as: transport of molecules through biological tissues, rationalization of physicochemical influences on biological responses, formulation of drugs in liquid and tablet dosage form, design of insecticides, and compatibility of prostheses with biological materials. Biological systems inevitably involve water, and therefore hydrogen bonding. As emphasized elsewhere, cohesion parameters are least successful when applied to systems with specific interactions like hydrogen bondingHansen parameters for materials of biological interest and Rey-Mermet, Kesselring and co-workers have conducted an extensive study of Hansen parameters of pharmaceutical solids. The long-term compatibility and performance of polymeric materials in physiological environments is of increasing importance. As well as adsorption of biological materials, polymer swelling resulting from absorption is also possible.
