Molds are potential health hazards by one or more of the three major mechanisms: allergy, toxic, or infectious. Several hundred species of molds such as Cladosporium, Mucor, Rhizopus, Fusarium, Alternaria, Penicillium, and Aspergillus commonly grow in indoor environments. Many patients are hypersensitive to molds and mycotoxins. Allergens are the most common mold problems. There are four cornerstones of the management of mold infections of the central nervous system: early diagnosis, administration of antifungal chemotherapy, neurosurgical assessment and intervention, and management of immunologic impairment. Mold in buildings emphasized the new awareness of problems from storms particularly from hurricanes. Life-threatening infant pulmonary hemorrhage has been associated with high indoor exposures to indoor water damage and high levels of Aspergillus and Stachybotrys molds. Mold can go to the hypothalamus and the rest of the limbic system causing neurodegenerative disease, arteriosclerosis, cancer, and many other brain dysfunctions.