ABSTRACT
Over the last two decades, signicant progress has been made in the development of biocompatible and biodegradable materials used in biomedical applications. For the biomedical eld, the goal is to develop and characterize articial materials or, in other words, “spare parts” for use in the human body to measure, restore, and improve physiologic functions, and enhance survival and quality of life. Typically, inorganic and polymeric materials have been used as articial heart valves, synthetic blood vessels, articial hips, medical adhesives, sutures, dental composites, and polymers for controlled slow drug delivery. The development of new biocompatible materials includes considerations that go beyond nontoxicity to bioactivity as it relates to interacting with and, in time, being integrated into the biological
11.1 Introduction .................................................................................................. 175 11.2 Basic Materials and Methods Used in Controlling the Release
of a Drug for Alzheimer’s Disease ............................................................... 176 11.3 Mathematical Patterns of the Controlled-Release Kinetics .......................... 178 11.4 Analysis of Donepezil Release for Polymorph A and Polymorph B at
Different Sizes of the Particles ..................................................................... 180 11.4.1 Donepezil (BPMDMDHI)–Polymorph A ........................................ 181 11.4.2 Donepezil (BPMDMDHI)–Polymorph B ........................................ 183
11.5 Induced Birefringence and the Inuence of the Stretching Process on the Donepezil Release from the PVA Foils .................................................. 184
11.6 Conclusions ................................................................................................... 187 References .............................................................................................................. 188
environment as well as other tailored properties depending on the specic “in vivo” application.
