ABSTRACT
You can compute the native structures of some proteins from their amino acid sequences. This is important because knowing a native structure is the starting point for understanding a protein’s dynamics, its binding partners, and its biological mechanism of action, and for designing drugs. Computational structure prediction can fill a big gap, since the number of known protein structures is fewer than onethousandth of the number of known amino acid sequences. We describe here some of the methods for computing protein structures.
