ABSTRACT
A genome sequence is not an end in itself. Major challenges still have to be met in locating the genes and other interesting features within the genome sequence and assigning functions to those genes whose roles are unknown. These challenges can be addressed by a combination of computer analysis and experimentation, but a complete description of a genome is rarely possible. Even though the finished version of the human genome sequence has been available since 2004, there are still uncertainties regarding the number of genes in the genome, and many of the identified genes have unknown functions. The development of new methods for understanding genome sequences is one of the central goals of genomics research.
