ABSTRACT

In this chapter we further explore the hypothesis explaining Gompertz-like tumor growth kinetics proposed by Gyllenberg and Webb. They extended their original quiescence model (section 2.4) to a more sophisticated framework that increases the realism beyond what simple models from Chapter 2 can handle. This new framework also introduces an important modeling feature—physiological stage structure (see [9] for an introduction to such models; detailed theory can be found in [4, 5]). These models, like the MCS models of Chapter 3, are based on partial differential equations.