ABSTRACT

Abstract ......................................................................................................24 2.1 Introduction .......................................................................................24 2.2 Etiology .............................................................................................25 2.3 Molecular Epidemiology ..................................................................27 2.4 Transmission .....................................................................................28 2.5 Glycobiology of Leishmania donovani .............................................29 2.6 Sandfly-Leishmania Interactions .....................................................31 2.7 Leishmania-Macrophage Interactions ..............................................32 2.8 Antimicrobial Peptides with Leishmania and their

Functional Role in Host Parasitism ..................................................41 2.9 Biochemical Targets for Therapy ......................................................45 2.10 Drug Delivery Systems .....................................................................50 2.11 Current Therapies..............................................................................65 Keywords ...................................................................................................92 References ..................................................................................................95

PART II PHARMACOLOGY OF LEISHMANIASIS