ABSTRACT
The concept of bioavailability enhancing is well documented in Ayurvedic texts. Bioavailability enhancers have been described as Yogvahidravya in Ayurveda. Honey and Trikatu are typical examples of bioavailability enhancer’s agents. Bioenhancers or bioavailability enhancers are a novel chapter in medical sciences and it was first scientifically established in 1979 after the discovery of piperine. Bioenhancers of herbal origin have demonstrated a significant role in enhancing the bioavailability and bioefficacy of antihypertensives, anticancer, antiviral, antitubercular, and antifungal drugs at low doses. Zingiber officinale is used in the range of 10-30 mg/kg body weight acts as a bioenhancer. It has shown to increase the bioavailability of Azithromycin, Cephalexin, Cefadroxil, Amoxycillin, Cloxacillin and Erythromycin. Glycyrrhizin present in G. glabra has been reported to increase the bioavailability of taxol, the anticancer molecule in the breast cancer cell line. The inhibition of cancerous cell growth by taxol in the presence of glycyrrhizin was higher than treatment with taxol alone.
