ABSTRACT
The steroidal alkaloids represent an important class of alkaloids that essentially afford a close structural relationship to sterols, that is, they contain a perhydro-1, 2-cyclopentanophenanthrene nucleus. Steroid alkaloids invariably occur in the plant kingdom as glucosidal combination with carbohydrate moieties. Solanum-type alkaloids are found in plants in the form of glycosides of alkaloids. Glycosides are ethers that join a noncarbohydrate moiety, the aglycone, by an ester bond to a carbohydrate moiety. Two new cevanine steroidal alkaloids, impericine and forticine, along with known bases delavine, persicanidine A, and imperialine were isolated. The alkaloids showed anti-acetylcholinesterase and anti-butyrylcholinesterase inhibitory activity. The chapter aims to screen potato glycoalkaloids for cytotoxicity in a range of cancerous cell lines. Cyclopamine has teratogen potential as it causes usually fatal birth defects. Cyclopamine can result in holoprosencephaly prevents the fetal brain from dividing into two lobes, holoprosencephaly, and cyclopia the development of a single eye. Cyclopamine causes holoprosencephaly and cyclopia by inhibiting the hedgehog signaling pathway.
