ABSTRACT
The optic vesicle is fully formed by day 25 of gestation and after it invaginates the thickened inner invaginated layer, known as the retinal disc, is destined to differentiate into the neural retina whereas the outermost layer of the optic cup is destined to become the retinal pigment epithelium (RPE). There is a sharp transition between these two layers at the optic cup margin.
