ABSTRACT
Colchicine from meadow saffron ( ■ Colchicum autumnale): in patients who do not respond to NSAIDs ❚ acts in gout possibly by blocking migration of neutrophils into the ❚ affected joint mechanism is by binding to the intracellular protein tubulin and ❚ blocking formation of microtubules adverse effects include diarrhoea, nausea and vomiting ❚ contraindicated in pregnancy and used with caution in the elderly and ❚ in patients with heart, kidney or GIT disease.
