Drug Delivery to the Female Reproductive Tract

Delivery of drugs to the vagina was thought to be limited to topical administration until 1918, when Macht reported systemic absorption of vaginally dosed morphine, atropine, and potassium iodide. Nearly a century later, drug delivery to the female reproductive tract (FRT), most notably the uterus and vagina, has become an essential component of female reproductive health. Previous reviews largely focused on vaginal delivery; however, due to the connectivity of the reproductive organs, we believe the whole FRT should be considered.