ABSTRACT
Introduction 133 Nodular lymphocyte-predominant Hodgkin lymphoma 134 Immunophenotype 136 Genetics 136 Differential diagnosis 136 Classical Hodgkin lymphoma 137 Immunohistochemistry 138 Genetics 139 Epstein-Barr virus 139 Nodular sclerosis classical Hodgkin lymphoma 139
Grading140 Lymphocyte-rich classical Hodgkin lymphoma 142 Immunohistochemistry 143 Differential diagnosis 143 Mixed cellularity classical Hodgkin lymphoma 143 Lymphocyte-depleted classical Hodgkin lymphoma 144 Association of classical Hodgkin lymphoma with
non-Hodgkin lymphoma 145 Differential diagnosis of classical Hodgkin lymphoma 145 References146
Hodgkin lymphoma occupies an enigmatic place among malignant lymphomas. Thomas Hodgkin was appointed to the post of Inspector of the Dead and Curator of the Museum at Guy’s Hospital in 1826. In his role as a morbid anatomist, he noted a peculiar appearance of the lymph nodes and spleen in six patients and was shown paintings of a similar case from France by his friend Robert Carswell, the first professor of pathology at University College Hospital. Hodgkin presented details of these cases in two lectures given to the Medical-Chirurgical Society in 1832 that were subsequently published in the transactions of that society under the title ‘On some morbid appearances of the absorbent glands and spleen’. This paper would have probably faded into obscurity had not Sir Samuel Wilks, a distinguished physician at Guy’s Hospital, described similar cases between 1856 and 1877 and, noting Dr. Hodgkin’s precedence, named them as Hodgkin’s disease.
