ABSTRACT
An excellent way of grasping this basic concept is to remember how often we co-prescribe two or more potent drugs to in order to 'normalise' pathophysiology. Everyday examples include the following: Doctors are well aware of such synergistic prescribing, which includes the treatment of asthma, type 2 diabetes and hyperlipidaemia. It is worth revising several important adverse drug interactions in treatment regimens for cardiovascular disease, asthma and the specialist-led treatment of depression and psychosis. As showed, in regimens for hypertension and congestive heart failure (CHF), NSAIDs will cause significant deterioration of control. A ‘wonder-drug’ group now widely available without prescription is the erection enhancer’s sildenafil, tadalafil and vardenafil. As showed, men who are using an erection enhancer should not take grapefruit juice, grapefruit or bitter oranges, as they increase the bioavailability of the erection enhancers.
