ABSTRACT
Non-specific urethritis is inflammation of the urethra, due to an unknown cause but identified as not being due to a gonococcal infection. Other possible causes of non-specific urethritis include sexually transmitted infections with Chlamydia trachomatis, Trichomonas vaginalis, Mycoplasma genitalium and genital Herpes simplex virus. Non-specific urethritis is most frequently diagnosed in males, as the disease in females is often asymptomatic. However, if untreated, non-specific urethritis due to chlamydia or mycoplasmamay lead to pelvic inflammatory disease in women. Many cases of non-specific urethritis are asymptomatic, but when symptoms do present they may be different in males and females. Tests are used to confirm urethritis and rule out gonococcal and chlamydia infections. Antibiotics are the standard therapy for non-gonococcal, non-specific urethritis. Hans Reiter's syndrome can be treated with Non-steroidal anti-inflammatory drugs (NSAID) or corticosteroid therapy to reduce inflammation and pain. Epididymo-orchitis is treated with NSAIDs for the inflammation plus antibiotics for any suspected underlying bacterial infection.
