ABSTRACT
This chapter highlights capabilities of computational bioengineering through discussions of a variety of bioengineering problems, including orthopedic joint prostheses, bone remodeling, fixation devices, degeneration of load-bearing soft connective tissues and intervertebral discs and blood flow in the cardiovascular system. A computational framework that combines both experimental and computational approaches, describing subject-specific deterministic and probabilistic factors, has been developed to generate functional performance assessments of joint prostheses. A computational model has been developed to examine the functionalities of basic multicellular units and their roles in bone remodeling. Soft tissue instability can cause and accelerate joint tissue degeneration, especially in situations during accidental fall, high-speed sports, or traumatic events. Computational models can be developed to address such important challenges for the study of cancer and cancer metastases.
