ABSTRACT
Polymyxins are a class of antibiotic lipopeptides that are produced by non-ribosomal polypeptide synthesis. Polymyxins display a wide spectrum of antibacterial activity. They generally show their antimicrobial activity against Gram-negative bacteria through the disruption of both the inner and outer cell membranes. Pharmacophore study is conducted to visualize the bond interaction between hydrogen bond acceptor and donor from ligand and protein molecule. A molecular model describing the spatial arrangements of hydrogen donor and acceptor molecules with the properties of molecular surface and the spatial arrangements of atoms of interaction is known as a pharmacophore model. The pharmacophore property describing the stereochemistry of vancomycin is studied using the online tool “pharmit.” Polymyxin and vancomycin are both generally preferred as antibiotics of last resort. These are used to treat infections caused by multidrug-resistant microorganisms. Polymyxin is specifically used to treat Gram-negative bacteria while vancomycin attacks the Gram-positive bacteria.
