ABSTRACT
The LC-NMR system is comprised of an NMR spectrometer console, a superconducting magnet, a workstation, and a flow probe, all under the operation of specialized LC-NMR software. Chapter 4 describes the configuration of the LC-NMR system. The focus of the chapter is on NMR instrumentation with an emphasis on the sensitivity of NMR spectroscopy. This includes the magnetic field strength (sensitivity increases with magnetic field strength), the size and filling factor of the receiver coil (mass sensitivity increases with increasing fill factor and decreasing coil diameter), and the noise introduced during detection. Factors governing these parameters are addressed in sections on the magnet, probes (room temperature and cryoprobes), and micro-capillary flow probes versus micro-capillary tube probes (room temperature and cryoprobes). Advantages of tube probes versus flow probes are discussed along with added sensitivity afforded from cryoprobes and the micro-capillary configuration. Probe coil geometries and probe sensitivity comparisons are included.
