ABSTRACT
Immune deficiencies may be temporary or permanent wherein temporary immune deficiency are caused by sources that weaken the immune system and infections, like influenza and mononucleosis that can suppress the immune system. This chapter discusses hypersensitive reactions, autoimmune diseases, immunodeficiency diseases, and computational immunology and immune disorders. Type III hypersensitivity reactions are caused by the antigen-antibody or immune complexes deposits that can fix complement components C3a, 4a and 5a and are removed from circulation by the phagocytes. The antigen may be exogenous including chronic bacterial, viral, or parasitic infections, or endogenous. The autoimmune reaction creates an environment in which many immune cells are recruited that interact to produce cytokines like type I interferons by plasmacytoid dendritic cells and other mediators to produce a pro-inflammatory response that amplify the reaction, leading to a massive inflammation. Autoimmune diseases (AD) are chronic with multiple factors contributing to AD that cause a range of different AD.
