ABSTRACT
Analytical problems in the various fields of applied sciences, like biochemistry, analytical toxicology, radiochemistry, drug control, and environmental pollution, very often require qualitative information concerning the substance, impurity, or a component of a sample. A biochemical analysis includes a testing of urine, blood, tissues, etc. for the presence of particular components, extending from urea and glucose which are obligatorily tested to specific substances like methylmalonic acid. Their presence in quantities above or below normal levels can reflect in specific tissue damage, inherited metabolic disorders, blocked biosynthetic routes, microbial invasion, malfunction of the immune system, or drug toxicity. The identification procedures for inorganic pharmaceutical preparations, which are, after all, rarely found among drugs, are based mostly on the color, crystal, and amorphous precipitate, as well as vapor formation. Methods for the detection and estimation of impurities in pharmaceutical raw materials and dosage forms are of vital importance to the drug control laboratories.
