ABSTRACT
This chapter discusses simply gross tests for growth inhibition. However, they provide some perspective on the breadth of organisms affected by deoxypyridoxine and in a few cases permit some generalizations. Bradner and Clark tested the effects of deoxypyridoxine, using filter paper discs, on anaerobic microorganisms as part of a search for a screening test for anticancer drugs. Bacteroides pseudoramosus was most susceptible to deoxypyridoxine inhibition showing inhibition at 10 gg deoxypyridoxine per disc. The authors located only six in vivo studies of deoxypyridoxine in plants. Sundaram et al. demonstrated that deoxypyridoxine could inhibit the synthesis of niacin and ascorbic acid in germinating pulses. The severe effect of deoxypyridoxine on weight gain in guppies and turbot is typical of effects in higher animals. Liver aspartate aminotransferase in the deoxypyridoxine group was about 50% of the activity found with the B6-deficient diet alone.
