ABSTRACT
One possible application of membrane sensors is to monitor the dissolution tablets, capsules, and suppositories when the pharmaceutical form contains an ion to which the sensor responds selectively in a short time. The safety and efficiency of slow-release formulations must be demonstrated before they may be introduced into clinical use. Potassium chloride tablets are often administered in the form of sustained-release preparations. The potassium membrane sensor in conjunction with a potassium-free liquid junction reference electrode was connected to a pH/mV-meter to measure the EMF. Both commercial (sodium warfarin, sodium butabarbital, and sodium bicarbonate) and specially manufactured (sodium salicylate) tablets were used. Some in vitro studies performed by M. Yonese et al. showed that the amount of fluoride incorporated in a remineralization treatment can be increased substantially if the tooth is demineralized carefully prior to the remineralization. The prototype fluoride delivery device involved micronized calcium fluoride maintained at the tooth surface with a cellulose film.
